Gold nanoparticles have had a major impact on science and technology. Numerous sizes and shapes can be synthesized by relatively simple means, and they can be further assembled and processed for applications in nanophotonics, catalysis, and drug delivery. We are now working on gold mesostructures. Here, “mesostructure” refers to gold structures that have features at both nano (<100 nm) and macro (> 10 µm) scales. The simplest example is a gold nanowire with nanoscale cross-section but extended micron-scale length. Gold mesostructures can be synthesized by similar chemistry to nanoparticles, but they have not been as widely pursued despite their technological interest. This is due to the complex and poorly understood soft matter interface that leads to their synthesis, and to the difficulty in handling materials with this combination of scales. Our preliminary work contains several insights and experimental advances that will allow us to push this field forward to better understand mesostructured materials and make them more widely available.